Overview

The rescape program, which is short for regulatory evolution landscape simulator, simulates sequence evolution of an enhancer using a computational model of regulatory function based on the Segal model [1], a fitness penalization for misexpression, and forward population simulations. It was originally used by Bullaughey [2] to investigate nucleotide substitution processes in a regime of stabilizing selection for a particular regulatory output of simple toy enhancers. For an overview of the model and details on the implementation, please refer to the paper [2].

Documentation

See the rescape Manual

Obtaining code

Download a recent stable release: rescape-0.1.tgz

You can view the repository on GitHub: https://github.com/kbullaughey/rescape

The latest source can be obtained from GitHub as follows (you'll need git installed):

   git clone git://github.com/kbullaughey/rescape.git rescape
   

References

[1]	Segal E, Raveh-Sadka T, Schroeder M, Unnerstall U, Gaul U. Predicting expression patterns from regulatory sequence in Drosophila segmentation. Nature (2008) vol. 451 (7178) pp. 535-40
[2]	Bullaughey K. Changes in selective effects over time facilitate turnover of enhancer sequences. Genetics (2011) vol. 187 (2) pp. 567-82 [PDF]

Last updated: Sat Feb 12 09:37:59 CST 2011